SPRO
Spero Therapeutics
PE ratio, current and historical analysis
- Stocks
- Healthcare
- NASDAQ: SPRO
- PE Ratio
As at Jul 2, 2026, the SPRO stock has a price-to-earnings ratio of 8.15. This is based on the current EPS of $0.27 and the stock price of $2.2 per share.
SPRO PE ratio history
The mean historical PE ratio of Spero Therapeutics over the last nine years is 6.57. The current 8.15 P/E ratio is 24% higher than the historical average. In the past nine years, SPRO's PE ratio peaked in the Sep 2024 quarter at 16.75, with a price of $1.34 and an EPS of $0.08. The Sep 2018 quarter marked the lowest point at 0.14, with a price of $10.51 and an EPS of $74.11.
Spero Therapeutics PE ratio by year
| Year | PE ratio | PE change | Price | EPS |
|---|---|---|---|---|
| 2025 | 15.53 | N/A | $2.33 | $0.15 |
| 2024 | N/A | N/A | $1.03 | -$1.27 |
| 2023 | 3.42 | N/A | $1.47 | $0.43 |
| 2022 | N/A | N/A | $1.73 | -$1.23 |
| 2021 | N/A | N/A | $16.01 | -$2.91 |
| 2020 | N/A | N/A | $19.39 | -$3.52 |
| 2019 | N/A | N/A | $9.62 | -$3.35 |
| 2018 | N/A | N/A | $6.15 | -$2.6 |
| 2017 | N/A | N/A | $11.75 | -$17.82 |
| 2016 | N/A | N/A | N/A | -$95.87 |
| 2015 | N/A | N/A | N/A | -$53.11 |
Spero Therapeutics PE ratio by quarter (TTM)
| Year | PE ratio | PE change | Price | EPS |
|---|---|---|---|---|
| Mar 2026 | 8.67 | -44.17% | $2.34 | $0.27 |
| Dec 2025 | 15.53 | N/A | $2.33 | $0.15 |
| Sep 2025 | N/A | N/A | $1.88 | -$0.79 |
| Jun 2025 | N/A | N/A | $2.9 | -$0.98 |
| Mar 2025 | N/A | N/A | $0.72 | -$1.28 |
| Dec 2024 | N/A | N/A | $1.03 | -$1.27 |
| Sep 2024 | 16.75 | 338.48% | $1.34 | $0.08 |
| Jun 2024 | 3.82 | -2.3% | $1.3 | $0.34 |
| Mar 2024 | 3.91 | 14.33% | $1.72 | $0.44 |
| Dec 2023 | 3.42 | 10.32% | $1.47 | $0.43 |
| Sep 2023 | 3.1 | -74.34% | $1.21 | $0.39 |
| Jun 2023 | 12.08 | N/A | $1.45 | $0.12 |
| Mar 2023 | N/A | N/A | $1.45 | -$0.52 |
| Dec 2022 | N/A | N/A | $1.73 | -$1.23 |
| Sep 2022 | N/A | N/A | $2 | -$3.13 |
SPRO Price vs fair value
SPRO average PE ratio chart
What this chart measures
The Historical Valuation Regime chart shows where the stock's current valuation sits relative to its own historical valuation range over the selected lookback period.
This is a history-relative tool, not a market-relative percentile. It does not compare the stock to other companies. Instead, it compares each historical valuation reading to the stock's own past readings.
Percentile logic
The threshold lines are calculated them from the stock's real historical values using percentile interpolation. That is why some colored bands are narrow while others are wide: the band widths reflect how the stock actually traded through time.
Regime map
| Historical percentile | Regime | Chart meaning |
|---|---|---|
| 0-10 | Historically Low | Deep cheap zone |
| >10-25 | Below Average | Cheap relative to history |
| >25-75 | Average | Within the normal historical range |
| >75-90 | Above Average | Expensive relative to history |
| >90-100 | Historically High | Extreme or stretched valuation |
How to read each part
| Chart element | What it tells you |
|---|---|
| Main line | The actual historical valuation values over time for the selected metric. |
| Dashed horizontal lines | The stock's computed P10, P25, Median, P75, and P90 thresholds for the selected period. |
| Colored bands | The historical valuation zones between those thresholds. |
| Metric boxes | Current ratio, historical median, current percentile, and current regime. |
| Timeline strip | A condensed regime history showing how the stock moved between cheap, fair, and expensive states across each observation. |
Important metric definitions
Current Percentile is the percentile rank of the latest valid historical observation within the selected lookback range.
Current Regime is assigned directly from the latest observation's percentile bucket using the fixed 10 / 25 / 75 / 90 cutoffs shown above.
How to use it well
This chart is most useful for answering a narrow question: Is this stock trading high, low, or normal relative to its own history? It works best alongside growth, profitability, and forward-looking business analysis, because a stock can deserve a higher or lower regime if its business quality has changed.
SPRO's current P/E ratio is above the 3-year average, but it is lower than the 5-year average.
PE comparison
With a P/E of 8.15, SPRO stands below the Healthcare sector and the industry average. In comparison with its Healthcare sector average of 26.04, Spero Therapeutics's P/E is 69% lower.
SPRO PE vs peers
SPRO's PE ratio stands lower than its peer stocks IBM and DV.
| Stock name | PE ratio | Market cap |
|---|---|---|
| SPRO Spero Therapeutics Inc | 8.15 | $127.38M |
| IBM International Business Machines Corp | 25.11 | $272.12B |
| DV DoubleVerify Holdings Inc | 34.67 | $1.76B |
| FC Franklin Covey Co | N/A | $245.51M |
Frequently asked questions
What is Spero Therapeutics's PE ratio?
As of Jul 2, 2026, SPRO stock has a price to earnings ratio of 8.15.
What is the 3-year average PE ratio for Spero Therapeutics (SPRO)?
Over the last 3 years, the average price to earnings ratio for SPRO stock is 7.89.
What is the 5-year average PE ratio for Spero Therapeutics (SPRO)?
Over the last 5 years, the average price to earnings ratio for SPRO stock is 8.41.
What is the highest PE ratio for SPRO?
Over the last nine years, the quarterly PE ratio reached a historic high of 16.75 in the Sep 2024 quarter.
How does the current PE ratio for SPRO compare to its historical average?
SPRO's current price to earnings ratio is 24% above its 9-year historical average.
Why is Spero Therapeutics's PE ratio so low?
SPRO's stock price is trading at a lower multiple of earnings, which is why its PE ratio of 8.15 is considered low.
How is SPRO's PE ratio calculated (Spero Therapeutics PE ratio formula)?
The P/E ratio is obtained by dividing the latest price of a stock by its trailing twelve months EPS. As of today (Jul 2, 2026), Spero Therapeutics's stock price is $2.2. The earnings per share for the trailing twelve months (TTM) ending Mar 2026 is $0.27. Therefore, Spero Therapeutics's PE ratio for today is 8.15. PE RATIO(8.15) = STOCK PRICE($2.2) / TTM EPS($0.27)
All PE ratio stats are based on quarterly TTM periods, unless otherwise specified.