PTGX
Protagonist Therapeutics
PE ratio, current and historical analysis
- Stocks
- Healthcare
- NASDAQ: PTGX
- PE Ratio
The current PE ratio of PTGX can't be determined, as the TTM EPS of -$1.81 is negative. Protagonist Therapeutics's last PE ratio on record was 86.27 in September 2025.
PTGX PE ratio history
The mean historical PE ratio of Protagonist Therapeutics over the last nine years is 36.19. Over the past nine years, PTGX's PE ratio was at its highest in the Sep 2025 quarter at 86.27, with a price of $66.43 and an EPS of $0.77. The Dec 2024 quarter recorded the bottom point at 8.64, with a price of $38.6 and an EPS of $4.47.
Protagonist Therapeutics PE ratio by year
| Year | PE ratio | PE change | Price | EPS |
|---|---|---|---|---|
| 2025 | N/A | N/A | $87.34 | -$2.05 |
| 2024 | 8.64 | N/A | $38.6 | $4.47 |
| 2023 | N/A | N/A | $22.93 | -$1.39 |
| 2022 | N/A | N/A | $10.91 | -$2.6 |
| 2021 | N/A | N/A | $34.2 | -$2.71 |
| 2020 | N/A | N/A | $20.16 | -$1.92 |
| 2019 | N/A | N/A | $7.05 | -$2.98 |
| 2018 | N/A | N/A | $6.73 | -$1.74 |
| 2017 | N/A | N/A | $20.8 | -$2.09 |
| 2016 | N/A | N/A | $21.99 | -$5.8 |
| 2015 | N/A | N/A | N/A | -$59.32 |
| 2014 | N/A | N/A | N/A | -$49.38 |
Protagonist Therapeutics PE ratio by quarter (TTM)
| Year | PE ratio | PE change | Price | EPS |
|---|---|---|---|---|
| Mar 2026 | N/A | N/A | $105.4 | -$1.81 |
| Dec 2025 | N/A | N/A | $87.34 | -$2.05 |
| Sep 2025 | 86.27 | 32.68% | $66.43 | $0.77 |
| Jun 2025 | 65.02 | 21.01% | $55.27 | $0.85 |
| Mar 2025 | 53.73 | 521.88% | $48.36 | $0.9 |
| Dec 2024 | 8.64 | -44.51% | $38.6 | $4.47 |
| Sep 2024 | 15.57 | 28.04% | $45 | $2.89 |
| Jun 2024 | 12.16 | 12.18% | $34.65 | $2.85 |
| Mar 2024 | 10.84 | N/A | $28.93 | $2.67 |
| Dec 2023 | N/A | N/A | $22.93 | -$1.39 |
| Sep 2023 | N/A | N/A | $16.68 | -$2.63 |
| Jun 2023 | N/A | N/A | $27.62 | -$2.69 |
| Mar 2023 | N/A | N/A | $23 | -$2.85 |
| Dec 2022 | N/A | N/A | $10.91 | -$2.6 |
| Sep 2022 | N/A | N/A | $8.43 | -$2.68 |
PTGX Price vs fair value
PTGX average PE ratio chart
What this chart measures
The Historical Valuation Regime chart shows where the stock's current valuation sits relative to its own historical valuation range over the selected lookback period.
This is a history-relative tool, not a market-relative percentile. It does not compare the stock to other companies. Instead, it compares each historical valuation reading to the stock's own past readings.
Percentile logic
The threshold lines are calculated them from the stock's real historical values using percentile interpolation. That is why some colored bands are narrow while others are wide: the band widths reflect how the stock actually traded through time.
Regime map
| Historical percentile | Regime | Chart meaning |
|---|---|---|
| 0-10 | Historically Low | Deep cheap zone |
| >10-25 | Below Average | Cheap relative to history |
| >25-75 | Average | Within the normal historical range |
| >75-90 | Above Average | Expensive relative to history |
| >90-100 | Historically High | Extreme or stretched valuation |
How to read each part
| Chart element | What it tells you |
|---|---|
| Main line | The actual historical valuation values over time for the selected metric. |
| Dashed horizontal lines | The stock's computed P10, P25, Median, P75, and P90 thresholds for the selected period. |
| Colored bands | The historical valuation zones between those thresholds. |
| Metric boxes | Current ratio, historical median, current percentile, and current regime. |
| Timeline strip | A condensed regime history showing how the stock moved between cheap, fair, and expensive states across each observation. |
Important metric definitions
Current Percentile is the percentile rank of the latest valid historical observation within the selected lookback range.
Current Regime is assigned directly from the latest observation's percentile bucket using the fixed 10 / 25 / 75 / 90 cutoffs shown above.
How to use it well
This chart is most useful for answering a narrow question: Is this stock trading high, low, or normal relative to its own history? It works best alongside growth, profitability, and forward-looking business analysis, because a stock can deserve a higher or lower regime if its business quality has changed.
PE comparison
PTGX PE vs peers
| Stock name | PE ratio | Market cap |
|---|---|---|
| VIVS VivoSim Labs Inc. | 0.77 | $3.49M |
| ORMP Oramed Pharmaceuticals Inc | 1.44 | $156.34M |
| OMER Omeros Corp | 7.88 | $741.12M |
| OLMA Olema Pharmaceuticals Inc | N/A | $931.12M |
| ORIC Oric Pharmaceuticals Inc | N/A | $830.21M |
| PTGX Protagonist Therapeutics Inc | N/A | $6.61B |
Frequently asked questions
What is Protagonist Therapeutics's PE ratio?
The current price to earnings ratio of PTGX can't be calculated, as its EPS of -$1.81 is negative.
What is the 3-year average PE ratio for Protagonist Therapeutics (PTGX)?
The 3-year average PE ratio for PTGX stock is 36.03.
What is the 5-year average PE ratio for Protagonist Therapeutics (PTGX)?
The 5-year average PE ratio for PTGX stock is 36.03.
What is the highest PE ratio for PTGX?
The highest quarterly PE ratio in the last nine years has been 86.27 and it was in the Sep 2025 quarter.
All PE ratio stats are based on quarterly TTM periods, unless otherwise specified.