PTGX
Protagonist Therapeutics
PE ratio, current and historical analysis
- Stocks
- Healthcare
- NASDAQ: PTGX
- PE Ratio
As at Sep 23, 2026, the PTGX stock has a PE ratio of 114.63. This is based on the current EPS of $1.21 and the stock price of $138.7 per share.
PTGX PE ratio history
The mean historical PE ratio of Protagonist Therapeutics over the last ten years is 42.7. The current 114.63 PE ratio is 168% above the historical average. Over the past ten years, PTGX's PE ratio was at its highest in the Jun 2026 quarter at 101.31, with a price of $122.58 and an EPS of $1.21. The Dec 2024 quarter recorded the bottom point at 8.64, with a price of $38.6 and an EPS of $4.47.
Protagonist Therapeutics PE ratio by year
| Year | PE ratio | PE change | Price | EPS |
|---|---|---|---|---|
| 2025 | N/A | N/A | $87.34 | -$2.05 |
| 2024 | 8.64 | N/A | $38.6 | $4.47 |
| 2023 | N/A | N/A | $22.93 | -$1.39 |
| 2022 | N/A | N/A | $10.91 | -$2.6 |
| 2021 | N/A | N/A | $34.2 | -$2.71 |
| 2020 | N/A | N/A | $20.16 | -$1.92 |
| 2019 | N/A | N/A | $7.05 | -$2.98 |
| 2018 | N/A | N/A | $6.73 | -$1.74 |
| 2017 | N/A | N/A | $20.8 | -$2.09 |
| 2016 | N/A | N/A | $21.99 | -$5.8 |
| 2015 | N/A | N/A | N/A | -$59.32 |
| 2014 | N/A | N/A | N/A | -$49.38 |
Protagonist Therapeutics PE ratio by quarter (TTM)
| Year | PE ratio | PE change | Price | EPS |
|---|---|---|---|---|
| Jun 2026 | 101.31 | N/A | $122.58 | $1.21 |
| Mar 2026 | N/A | N/A | $105.4 | -$1.81 |
| Dec 2025 | N/A | N/A | $87.34 | -$2.05 |
| Sep 2025 | 86.27 | 32.68% | $66.43 | $0.77 |
| Jun 2025 | 65.02 | 21.01% | $55.27 | $0.85 |
| Mar 2025 | 53.73 | 521.88% | $48.36 | $0.9 |
| Dec 2024 | 8.64 | -44.51% | $38.6 | $4.47 |
| Sep 2024 | 15.57 | 28.04% | $45 | $2.89 |
| Jun 2024 | 12.16 | 12.18% | $34.65 | $2.85 |
| Mar 2024 | 10.84 | N/A | $28.93 | $2.67 |
| Dec 2023 | N/A | N/A | $22.93 | -$1.39 |
| Sep 2023 | N/A | N/A | $16.68 | -$2.63 |
| Jun 2023 | N/A | N/A | $27.62 | -$2.69 |
| Mar 2023 | N/A | N/A | $23 | -$2.85 |
| Dec 2022 | N/A | N/A | $10.91 | -$2.6 |
PTGX Price vs fair value
PTGX average PE ratio chart
What this chart measures
The Historical Valuation Regime chart shows where the stock's current valuation sits relative to its own historical valuation range over the selected lookback period.
This is a history-relative tool, not a market-relative percentile. It does not compare the stock to other companies. Instead, it compares each historical valuation reading to the stock's own past readings.
Percentile logic
The threshold lines are calculated them from the stock's real historical values using percentile interpolation. That is why some colored bands are narrow while others are wide: the band widths reflect how the stock actually traded through time.
Regime map
| Historical percentile | Regime | Chart meaning |
|---|---|---|
| 0-10 | Historically Low | Deep cheap zone |
| >10-25 | Below Average | Cheap relative to history |
| >25-75 | Average | Within the normal historical range |
| >75-90 | Above Average | Expensive relative to history |
| >90-100 | Historically High | Extreme or stretched valuation |
How to read each part
| Chart element | What it tells you |
|---|---|
| Main line | The actual historical valuation values over time for the selected metric. |
| Dashed horizontal lines | The stock's computed P10, P25, Median, P75, and P90 thresholds for the selected period. |
| Colored bands | The historical valuation zones between those thresholds. |
| Metric boxes | Current ratio, historical median, current percentile, and current regime. |
| Timeline strip | A condensed regime history showing how the stock moved between cheap, fair, and expensive states across each observation. |
Important metric definitions
Current Percentile is the percentile rank of the latest valid historical observation within the selected lookback range.
Current Regime is assigned directly from the latest observation's percentile bucket using the fixed 10 / 25 / 75 / 90 cutoffs shown above.
How to use it well
This chart is most useful for answering a narrow question: Is this stock trading high, low, or normal relative to its own history? It works best alongside growth, profitability, and forward-looking business analysis, because a stock can deserve a higher or lower regime if its business quality has changed.
PTGX's current P/E ratio is above the 3, 5 and 10-year historical averages.
PE comparison
Protagonist Therapeutics's P/E of 114.63 is above the Healthcare sector and the industry average. Compared to its Healthcare sector average of 23.69, Protagonist Therapeutics's P/E is 384% higher.
PTGX PE vs peers
Frequently asked questions
What is Protagonist Therapeutics's PE ratio?
The price to earnings ratio for PTGX stock is 114.63 as of Sep 23, 2026.
What is the 3-year average PE ratio for Protagonist Therapeutics (PTGX)?
The 3-year average PE ratio for PTGX stock is 44.19.
What is the 5-year average PE ratio for Protagonist Therapeutics (PTGX)?
The 5-year average PE ratio for PTGX stock is 44.19.
What is the highest PE ratio for PTGX?
The current P/E of 114.63 represents the highest historical value in the last ten years.
How does the current PE ratio for PTGX compare to its historical average?
PTGX's current price to earnings ratio is 168% above its 10-year historical average.
Why is Protagonist Therapeutics's PE ratio so high?
PTGX's PE ratio of 114.63 is considered high because the company's stock price is trading at a higher multiple of earnings.
How is PTGX's PE ratio calculated (Protagonist Therapeutics PE ratio formula)?
To determine the PE ratio, divide the most recent stock price by the TTM earnings per share (EPS). As of today (Sep 23, 2026), Protagonist Therapeutics's stock price is $138.7. The earnings per share for the trailing twelve months (TTM) ending Jun 2026 is $1.21. Therefore, Protagonist Therapeutics's P/E ratio for today is 114.63. PE RATIO(114.63) = STOCK PRICE($138.7) / TTM EPS($1.21)
All PE ratio stats are based on quarterly TTM periods, unless otherwise specified.