KRYS
Krystal Biotech
PE ratio, current and historical analysis
- Stocks
- Healthcare
- NASDAQ: KRYS
- PE Ratio
As of Jun 3, 2026, the KRYS stock has a PE ratio of 38.94. The calculation is based on the latest EPS of $7.75 and the stock price of $301.82 per share. An increase of 29% has been observed in the PE ratio compared to its average of 30.2 of the last four quarters.
KRYS PE ratio history
The mean historical PE ratio of Krystal Biotech over the last nine years is 69.14. The current 38.94 P/E ratio is 44% lower than the historical average. Looking back at the last nine years, KRYS's PE ratio peaked in the Dec 2023 quarter at 310.15, with a price of $124.06 and an EPS of $0.4. The Sep 2017 quarter marked the lowest point at 0.27, with a price of $9.97 and an EPS of $37.27.
Krystal Biotech PE ratio by year
Maximum annual decrease: -83.81% in 2024
| Year | PE ratio | PE change | Price | EPS |
|---|---|---|---|---|
| 2025 | 34.82 | -30.65% | $246.54 | $7.08 |
| 2024 | 50.21 | -83.81% | $156.66 | $3.12 |
| 2023 | 310.15 | N/A | $124.06 | $0.4 |
| 2022 | N/A | N/A | $79.22 | -$5.49 |
| 2021 | N/A | N/A | $69.95 | -$3.13 |
| 2020 | N/A | N/A | $60 | -$1.71 |
| 2019 | N/A | N/A | $55.38 | -$1.2 |
| 2018 | N/A | N/A | $20.78 | -$0.97 |
| 2017 | N/A | N/A | $10.52 | -$1.48 |
| 2016 | N/A | N/A | N/A | -$1.31 |
Krystal Biotech PE ratio by quarter (TTM)
| Year | PE ratio | PE change | Price | EPS |
|---|---|---|---|---|
| Mar 2026 | 33.33 | -4.28% | $258.32 | $7.75 |
| Dec 2025 | 34.82 | 36.12% | $246.54 | $7.08 |
| Sep 2025 | 25.58 | -4.91% | $176.53 | $6.9 |
| Jun 2025 | 26.9 | -35.55% | $137.46 | $5.11 |
| Mar 2025 | 41.74 | -16.87% | $180.3 | $4.32 |
| Dec 2024 | 50.21 | -49.25% | $156.66 | $3.12 |
| Sep 2024 | 98.93 | 103.1% | $182.03 | $1.84 |
| Jun 2024 | 48.71 | -45.79% | $183.64 | $3.77 |
| Mar 2024 | 89.86 | -71.03% | $177.93 | $1.98 |
| Dec 2023 | 310.15 | N/A | $124.06 | $0.4 |
| Sep 2023 | N/A | N/A | $116 | -$1.38 |
| Jun 2023 | N/A | N/A | $117.4 | -$5.43 |
| Mar 2023 | N/A | N/A | $80.06 | -$5.28 |
| Dec 2022 | N/A | N/A | $79.22 | -$5.49 |
| Sep 2022 | N/A | N/A | $69.7 | -$5.21 |
KRYS Price vs fair value
KRYS average PE ratio chart
What this chart measures
The Historical Valuation Regime chart shows where the stock's current valuation sits relative to its own historical valuation range over the selected lookback period.
This is a history-relative tool, not a market-relative percentile. It does not compare the stock to other companies. Instead, it compares each historical valuation reading to the stock's own past readings.
Percentile logic
The threshold lines are calculated them from the stock's real historical values using percentile interpolation. That is why some colored bands are narrow while others are wide: the band widths reflect how the stock actually traded through time.
Regime map
| Historical percentile | Regime | Chart meaning |
|---|---|---|
| 0-10 | Historically Low | Deep cheap zone |
| >10-25 | Below Average | Cheap relative to history |
| >25-75 | Average | Within the normal historical range |
| >75-90 | Above Average | Expensive relative to history |
| >90-100 | Historically High | Extreme or stretched valuation |
How to read each part
| Chart element | What it tells you |
|---|---|
| Main line | The actual historical valuation values over time for the selected metric. |
| Dashed horizontal lines | The stock's computed P10, P25, Median, P75, and P90 thresholds for the selected period. |
| Colored bands | The historical valuation zones between those thresholds. |
| Metric boxes | Current ratio, historical median, current percentile, and current regime. |
| Timeline strip | A condensed regime history showing how the stock moved between cheap, fair, and expensive states across each observation. |
Important metric definitions
Current Percentile is the percentile rank of the latest valid historical observation within the selected lookback range.
Current Regime is assigned directly from the latest observation's percentile bucket using the fixed 10 / 25 / 75 / 90 cutoffs shown above.
How to use it well
This chart is most useful for answering a narrow question: Is this stock trading high, low, or normal relative to its own history? It works best alongside growth, profitability, and forward-looking business analysis, because a stock can deserve a higher or lower regime if its business quality has changed.
The current PE ratio of KRYS is lower than its 3 and 5-year averages.
PE comparison
Krystal Biotech's price to earnings (P/E) of 38.94 is higher than the Healthcare sector and the industry average. In comparison with the Healthcare sector average of 23.02, Krystal Biotech's price to earnings (P/E) is 69% higher.
KRYS PE vs peers
In comparison to its peer stocks OMER and ORMP, KRYS's PE ratio is higher.
| Stock name | PE ratio | Market cap |
|---|---|---|
| VIVS VivoSim Labs Inc. | 0.77 | $3.49M |
| ORMP Oramed Pharmaceuticals Inc | 1.44 | $156.34M |
| OMER Omeros Corp | 7.88 | $741.12M |
| KRYS Krystal Biotech Inc | 39.67 | $9.06B |
| OLMA Olema Pharmaceuticals Inc | N/A | $931.12M |
| ORIC Oric Pharmaceuticals Inc | N/A | $830.21M |
Frequently asked questions
What is Krystal Biotech's PE ratio?
KRYS stock has a price to earnings ratio of 38.94 as of Jun 3, 2026.
What is the 3-year average PE ratio for Krystal Biotech (KRYS)?
As an average over the last 3 years, KRYS stock has a PE ratio of 76.02.
What is the 5-year average PE ratio for Krystal Biotech (KRYS)?
As an average over the last 5 years, KRYS stock has a PE ratio of 76.02.
What is the highest PE ratio for KRYS?
Over the last nine years, the Dec 2023 quarter recorded the highest quarterly PE ratio at 310.15.
How does the current PE ratio for KRYS compare to its historical average?
KRYS's current price to earnings ratio is 44% below its 9-year historical average.
How is KRYS's PE ratio calculated (Krystal Biotech PE ratio formula)?
The P/E ratio is obtained by dividing the latest price of a stock by its trailing twelve months EPS. As of today (Jun 3, 2026), Krystal Biotech's share price is $301.82. The company's earnings per share for the trailing twelve months (TTM) ending Mar 2026 is $7.75. Therefore, Krystal Biotech's PE ratio for today is 38.94. PE RATIO(38.94) = STOCK PRICE($301.82) / TTM EPS($7.75)
All PE ratio stats are based on quarterly TTM periods, unless otherwise specified.